Consider intramuscular vitamin B 12 injections instead of oral replacement for suspected or confirmed vitamin B 12 deficiency caused by diet if: The person has another condition that may deteriorate rapidly and have a major effect on their quality of life (for example, a neurological or hematological condition such as ataxia or anemia)
Most human studies used intravenous administration
3,32,40,62 Unlike DJS, RS results in increased total urinary coproporphyrin excretion because of the simultaneous absence of OATP1B1 and OATP1B3, which are responsible for the sinusoidal uptake of conjugated bilirubin and coproporphyrins from the blood into hepatocytes
Kelly AS, Auerbach P, Barrientos-Perez M, Gies I, Hale PM, Marcus C, et al
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